Industria Cosmética - Número 46

tolerabilidad, origen natural de las materias primas, biodegradabilidad y comportamiento ambiental. En este marco, Ethyl Lauroyl Arginate HCl reúne características de interés para la investigación de nuevas estrategias para el control de la caspa: rápida actividad frente a la reducción de M. furfur , eficacia clínica comprobada, perfil dermatológico favorable, origen natural y biodegradabilidad. Para los equipos de I+D, el siguiente paso consiste en trasladar esta evidencia a formulaciones específicas para el control de la caspa. Este enfoque permitirá avanzar hacia productos capilares que integren la eficacia microbiológica, el cuidado del cuero cabelludo y criterios de sostenibilidad NOTA FINAL Ingrediente patentado: La empresa VEDEQSA ha sido pionera en el desarrollo de Ethyl Lauroyl Arginate HCl en la UE, con un registro de patente para aplicaciones alimentarias y cosméticas, y es titular de los derechos de propiedad intelectual del ingrediente activo evaluado en este estudio. REFERENCIAS 1. Shah, R.R. et al. (2024). Scalp microbiome: a guide to better understanding scalp diseases and treatments. Arch Dermatol Res 2024, 316 (8): 495. Available online: https:// doi.org/10.1007/s00403-024-03235-2 2. Jung, WH. (2023). Alteration in skin mycobiome due to atopic dermatitis and seborrheic dermatitis. Biophys Rev (Melville). 2023 Mar 13;4(1). Available online: https://pubmed.ncbi. nlm.nih.gov/38505818/ 3. Borda L.J., & Wikramanayake T.C. (2015). Seborrheic dermatitis and dandruff: A comprehensive review. J Clin Investig Dermatol. 2015; 3 (2). Available online: https://doi. org/10.13188/2373-1044.1000019. 4. Trüeb, M. et al. (2019). Scalp Condition Impacts Hair Growth and Retention via Oxidative Stress. International Journal of Trichology. November-December 2018, 10 (6): 262-270 5. Newton-Fenner, A. et al . (2025). Clear scalp, clear mind: Examining the beneficial impact of dandruff reduction on physical, emotional and social wellbeing. Int J Cosmet Sci. 2025; 47: 466–475 . Available online: https://doi. org/10.1111/ics.13041 6. Deng, L. et al. (2026). Advances in Scalp Microbiome Research: Molecular Insights into the Metabolism-Inflammation-Barrier Axis and Dandruff Pathogenesis. Molecules 2026, 31 (12), 2093. Available online: https://www.mdpi.com/1420- 3049/31/12/2093 7. Ivanova, A. & Buzova, V. (2025). A novel enzymatic approach for a targeted fungal growth inhibition. BMC Microbiology (2025) 25:719. Available online: https://link.springer.com/ article/10.1186/s12866-025-04453-y 8. Mayser, P. et al. (2026). Market Transformation in Dandruff control: Recent Developments on Anti-Dandruff Active Ingredients. Cosmetics 2026, 13, 84. Available online: https://www. mdpi.com/2079-9284/13/2/84 9. Gupta, J. et al. (2026). Malassezia and Staphylococcus are associated with scalp seborrheic dermatitis. Med Mycol. 2026 Feb 3; 64(2) 10. EU Zinc Pyrithione Ban from Cosmetics: Commission Regulation (EU) 2021/1902 of 29 October 2021 Amending Annexes II, III and V to Regulation (EC) No 1223/2009 of the European Parliament and of the Council as Regards the Use in Cosmetic Products of Certain Substances Classified as Carcinogenic, Mutagenic or Toxic for Reproduction. Off. J. Eur. Union 2021, L387, 120–125. Available online: https://eur-lex. europa.eu/legal-content/EN/TXT/ PDF/?uri=CELEX:32021R1902 11. Balkrishna, A, et al. (2025). Anti- furfurative comparison of Kesh Kanti-Herbal Shampoos and synthetic shampoos against Malassezia furfur for dandruff management. AMB Express. 2025 Jan 13;15(1):8. Available online: https://pmc.ncbi.nlm.nih.gov/ articles/PMC11729601/ 12. Rodriguez, E. et al. (2004). Cellular effects of monohydrochloride of L-arginine, Na -lauroyl ethylester (LAE) on exposure to Salmonella typhimurium and Staphylococcus aureus . The Society for Applied Microbiology 2004, 96 (5): 903-912. DOI: 10.1111/j.1365-2672.2004.02207.x 13. Edward, M. J., & Norman, F. M. T. R. (2008). The controlled use test in a cosmetic product safety substantiation program. Journal of Toxicology: Cutaneous and Ocular Toxicology, 1 (2), 117–132. 14. Keswick B.H., Ertel K.D., Visscher M.O. (1992). Comparison of exaggerated and normal use techniques for assessing the mildness of personal cleansers. J. Soc. Cosm. Chem., 1992, 43, pp.187-193 15. Anastas, P. T. and Warner, J. C. (1998). Green Chemistry: Theory and Practice, Oxford University Press, New York, p. 30. 16. Communication from the Commission to the European Parliament, the European Council, the Council, the European Economic and Social Committee and the Committee of the Regions – The European Green Deal (COM (2019) 640 final, 11 December 2019). Available online: https://eur- lex.europa.eu/legal-content/EN/ TXT/?uri=CELEX:52019DC0640 17. Lipshutz, B. H. and Handa, H: (2026). Modernizing the 12 principles of green chemistry: it’s time. Green Chem. 2026; 28 (13): 5606–5612. Available online: https://doi.org/10.1039/d5gc05289k 18. Eurofins Cosmetics & Personal Care (Evic Hispania). 2011. Assessment in human of the anti-dandruff effect of several cosmetics products. Checking in human of their acceptability after application under normal conditions of use. Subjective assessment of their cosmetics qualities and efficacy. Barcelona, Spain. 19. Ethyl Lauroyl Arginate HCl. EWG’s Skin Deep. Available online: https://www.ewg.org/skindeep/ ingredients/718968-ETHYL_LAUROYL_ ARGINATE_HCL/ 20. Minguet, M. et al. (2011). Ethyl Lauroyl Arginate HCl for Natural Preservation. Cosmetics & Toiletries magazine. December 2011, 126, 12: 876-883. Available online: https:// www.cosmeticsandtoiletries.com/ cosmetic-ingredients/preservation/ article/21834842/ethyl-lauroyl- arginate-hcl-for-natural-preservation 51 OTOÑO 2026 INDUSTRIA COSMÉTICA 046 BIOTECNOLOGÍA COSMÉTICA